绝望的英文表达是"despair"。这个词源自拉丁语的"desperare"，意思是"失去希望"。例句：

She felt a deep sense of despair after losing her job. 她失业后感到绝望。

His voice was filled with despair as he begged for help. 他恳求帮助时，声音里充满了绝望。

绝望这个词也可以用作名词，指"绝望的状态"。例句：

The poverty and disease in this region have caused despair among the people. 这个地区的贫穷和疾病已经让人民陷入了绝望。

She struggled to overcome the despair that threatened to consume her. 她努力克服那种几乎要吞噬她的绝望。